This course trains driver-trainees on FMCSA regulations (49 CFR Part 382) for alcohol and controlled substances, including prescription and over-the-counter drugs, for CMV drivers. Trainees learn about required tests (pre-employment, random, post-accident, reasonable suspicion, return-to-duty, follow-up), testing procedures, and consequences like removal from duty, Substance Abuse Professional evaluation, and Drug and Alcohol Clearinghouse entries impacting CDL and jobs. Strategies for compliance include managing medications, adhering to alcohol rules, cooperating with tests, and seeking help for substance issues, reinforced through practical scenarios to ensure safe, professional CMV operation.